This page lists people with the surname Makriyannis. Alexandros Makriyannis, ands 3 research works with 142 citations and 141 reads, including: Synthesis of Covalent Probes for the Radiolabeling of the.
Yannis Makriyannis (17971864), Greek merchant, military author, politician, and author. These studies may lead to better strategies for treatment modalities targeted to the BBB following HIV-1 infection of the brain based on cannabinoid pharmacotherapies. Notable people with the surname include: Alexandros Makriyannis (born 1939), American medical researcher. These results demonstrate that cannabinoid agonists are able to restore the integrity of HBMEC and the BBB following insults by HIV-1 Gp120. Nikolai Zvonok, Han Zhou, Irina Kufareva, Beili Wu, Qiang Zhao, Michael Hanson, Laura Bohn, Alexandros Makriyannis, Raymond Stevens, and Zhi-Jie Liu. He is a highly successful medicinal chemist and is well recognized nationally and internationally for his important contributions in endocannabinoid research. Furthermore, cannabinoid agonists inhibited the transmigration of human monocytes across the BBB and blocked the BBB permeability in vivo. Alex Makriyannis is the George Behrakis Chair of Pharmaceutical Biotechnology at Northeastern University, Boston, MA, and is the Founder and Director of the Center for Drug Discovery. Using cocultures of HBMEC and human astrocytes as a model system for human BBB as well as in vivo model, we show for the first time that cannabinoid agonists inhibited HIV-1 Gp120-induced calcium influx mediated by substance P and significantly decreased the permeability of HBMEC as well as prevented tight junction protein down-regulation of ZO-1, claudin-5, and JAM-1 in HBMEC. Cellular products and viral proteins secreted by HIV-1 infected cells, such as the HIV-1 Gp120 envelope glycoprotein, play important roles in BBB impairment and HIV-associated dementia development. Breakdown of the blood-brain barrier (BBB) is frequently observed in patients with HIV-associated dementia (HAD) despite lack of productive infection of human brain microvascular endothelial cells (HBMEC). Alexandros Makriyannis is a professor in the Department of Medicinal Chemistry at Northeastern University, where his research group has synthesized many new compounds with cannabinoid activity. HIV-1 infection has significant effect on the immune system as well as on the nervous system.
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